A Novel Cis-Acting RNA Structural Element Embedded in the Core Coding Region of the Hepatitis C Virus Genome Directs Internal Translation Initiation of the Overlapping Core+1 ORF

Hepatitis C virus (HCV) genome translation is initiated via an internal ribosome entry site (IRES) embedded in the 5′-untranslated region (5′UTR). We have earlier shown that the conserved RNA stem-loops (SL) SL47 and SL87 of the HCV core-encoding region are important for viral genome translation in...

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Udgivet i:Int J Mol Sci
Main Authors: Vassilaki, Niki, Frakolaki, Efseveia, Kalliampakou, Katerina I., Sakellariou, Panagiotis, Kotta-Loizou, Ioly, Bartenschlager, Ralf, Mavromara, Penelope
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554737/
https://ncbi.nlm.nih.gov/pubmed/32972019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186974
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