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The Reversible Non-covalent Aggregation Into Fibers of PGLa and Magainin 2 Preserves Their Antimicrobial Activity and Synergism

Magainin 2 and PGLa are antimicrobial peptides found together in frog skin secretions. When added as a mixture they show an order of magnitude increase in antibacterial activity and in model membrane permeation assays. Here we demonstrate that both peptides can form fibers with beta-sheet/turn signa...

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Dettagli Bibliografici
Pubblicato in:Front Cell Infect Microbiol
Autori principali: Juhl, Dennis Wilkens, Glattard, Elise, Lointier, Morane, Bampilis, Panos, Bechinger, Burkhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554302/
https://ncbi.nlm.nih.gov/pubmed/33102247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.526459
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