Structural basis for STAT2 suppression by flavivirus NS5

Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy viruses use to establish infections, yet the detailed mechanism remains elusive due to lack of structural information of the viral-cellular complex involved. Here, we report the cryo-EM and crystal structures of...

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Publicat a:Nat Struct Mol Biol
Autors principals: Wang, Boxiao, Thurmond, Stephanie, Zhou, Kang, Sánchez-Aparicio, Maria T., Fang, Jian, Lu, Jiuwei, Gao, Linfeng, Ren, Wendan, Cui, Yanxiang, Veit, Ethan C, Hong, HeaJin, Evans, Matthew J, O’Leary, Seán E., García-Sastre, Adolfo, Zhou, Z. Hong, Hai, Rong, Song, Jikui
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554153/
https://ncbi.nlm.nih.gov/pubmed/32778820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0472-y
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