LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice

The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion. Here, we report that deleting Pinch1 in limb mesenchymal stem cells (MSCs) and Pinch2 globally (double knockout; dKO) in mice causes severe chondrodysplasia, while single...

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Pubblicato in:Bone Res
Autori principali: Lei, Yiming, Fu, Xuekun, Li, Pengyu, Lin, Sixiong, Yan, Qinnan, Lai, Yumei, Liu, Xin, Wang, Yishu, Bai, Xiaochun, Liu, Chuanju, Chen, Di, Zou, Xuenong, Cao, Xu, Cao, Huiling, Xiao, Guozhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553939/
https://ncbi.nlm.nih.gov/pubmed/33083097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00108-y
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