The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium

Acute inflammation begins with leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin on inflamed endothelium and platelets. In pathologic conditions, this process may contribute to secondary organ damage, like sepsis-induced liver injury. Therefore, developing novel therapies to...

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Publicado en:PLoS One
Autores principales: Lam, Fong Wilson, Brown, Cameron August, Valladolid, Christian, Emebo, Dabel Cynthia, Palzkill, Timothy Gerald, Cruz, Miguel Angel
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553327/
https://ncbi.nlm.nih.gov/pubmed/33048962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240164
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