Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate

The COVID-19 pandemic caused by SARS-CoV-2 is in immediate need of an effective antidote. Although the Spike glycoprotein (SgP) of SARS-CoV-2 has been shown to bind to heparins, the structural features of this interaction, the role of a plausible heparan sulfate proteoglycan (HSPG) receptor, and the...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Tiwari, Vaibhav, Tandon, Ritesh, Sankaranarayanan, Nehru Viji, Beer, Jacob C., Kohlmeir, Ellen K., Swanson-Mungerson, Michelle, Desai, Umesh R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553162/
https://ncbi.nlm.nih.gov/pubmed/33052337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.08.331751
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