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Combinatorial virtual library screening analysis of antithrombin binding oligosaccharide motif generation by heparan sulfate 3-O-Sulfotransferase 1()

Pharmaceutical heparin’s activity arises from a key high affinity and high selectivity antithrombin binding motif, which forms the basis for its use as an anticoagulant. The current problems with the supply of pig heparin raises the emphasis of understanding heparin biosynthesis so as to control and...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Sankaranarayanan, Nehru Viji, Bi, Yiling, Kuberan, Balagurunathan, Desai, Umesh R.
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183009/
https://ncbi.nlm.nih.gov/pubmed/32346466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.03.008
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