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Integrating CRISPR-Cas12a with a DNA circuit as a generic sensing platform for amplified detection of microRNA
CRISPR-based diagnostics (CRISPR-Dx) has shown great promise in molecular diagnostics, but its utility in the sensing of microRNA (miRNA) biomarkers is limited by sensitivity, cost and robustness. Here, we describe a CRISPR-Dx method for the sensitive and cost-effective detection of miRNAs by ration...
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| Publicat a: | Chem Sci |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7553042/ https://ncbi.nlm.nih.gov/pubmed/33133487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03084h |
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