Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis

BACKGROUND: CDKN2A hypermethylation is among the major events associated with carcinogenesis and is also observed in non-neoplastic colonic mucosa in patients with ulcerative colitis (UC). Macrophage migration inhibitory factor (MIF) plays a crucial role in promoting gastrointestinal inflammation ch...

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Veröffentlicht in:BMC Med Genet
Hauptverfasser: Sakurai, Naoko, Shibata, Tomoyuki, Nakamura, Masakatsu, Takano, Hikaru, Hayashi, Tasuku, Ota, Masafumi, Nomura-Horita, Tomoe, Hayashi, Ranji, Shimasaki, Takeo, Ostuka, Toshimi, Tahara, Tomomitsu, Arisawa, Tomiyasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552536/
https://ncbi.nlm.nih.gov/pubmed/33046033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-020-01140-9
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