Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins

Novel therapies to counteract multidrug-resistant gonorrhea are urgently needed. A unique gonococcal immune evasion strategy involves capping of lipooligosaccharide (LOS) with sialic acid by gonococcal sialyltransferase (Lst), utilizing host-derived CMP-sialic acid (CMP-Neu5Ac in humans). LOS sialyl...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: Gulati, Sunita, Schoenhofen, Ian C, Lindhout-Djukic, Theresa, Lewis, Lisa A, Moustafa, Iesha Y, Saha, Sudeshna, Zheng, Bo, Nowak, Nancy, Rice, Peter A, Varki, Ajit, Ram, Sanjay
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552427/
https://ncbi.nlm.nih.gov/pubmed/32692363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiaa438
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