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The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Genetic mutations and abnormal gene regulation are key mechanisms underlying tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores, represent the basic units of chromatin. The fifth amino group (N(ε)) of histone lysine residues is a common site for post-translational modifica...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Li, Guo, Tian, Yuan, Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552186/
https://ncbi.nlm.nih.gov/pubmed/33117804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.576946
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