M(2)-TAM subsets altered by lactic acid promote T-cell apoptosis through the PD-L1/PD-1 pathway

The aim of the study was to investigate the effects of lactic acid on the phenotypic polarization and immune function of macrophages. The human monocyte/macrophage cell line, THP-1, was selected and treated with lactic acid. Immunofluorescence staining, laser confocal microscopy, reverse-transcripti...

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Veröffentlicht in:Oncol Rep
Hauptverfasser: Shan, Tao, Chen, Shuo, Chen, Xi, Wu, Tao, Yang, Yi, Li, Shunle, Ma, Jiancang, Zhao, Jing, Lin, Wanrun, Li, Wei, Cui, Xijuan, Kang, Ya'an
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7551099/
https://ncbi.nlm.nih.gov/pubmed/33000216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2020.7767
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