Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Shp1, encoded by the gene Ptpn6, is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types. Blocking Shp1 activity represents an exciting potential immunotherapeutic strategy for the treatment of cancer, as Shp1 inhibition would be p...

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Publicado en:Front Immunol
Autores principales: Myers, Darienne R., Abram, Clare L., Wildes, David, Belwafa, Amira, Welsh, Alia M. N., Schulze, Christopher J., Choy, Tiffany J., Nguyen, Tram, Omaque, Neil, Hu, Yongmei, Singh, Mallika, Hansen, Rich, Goldsmith, Mark A., Quintana, Elsa, Smith, Jacqueline A. M., Lowell, Clifford A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550718/
https://ncbi.nlm.nih.gov/pubmed/33133093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.576310
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