Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Shp1, encoded by the gene Ptpn6, is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types. Blocking Shp1 activity represents an exciting potential immunotherapeutic strategy for the treatment of cancer, as Shp1 inhibition would be p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Immunol
Egile Nagusiak: Myers, Darienne R., Abram, Clare L., Wildes, David, Belwafa, Amira, Welsh, Alia M. N., Schulze, Christopher J., Choy, Tiffany J., Nguyen, Tram, Omaque, Neil, Hu, Yongmei, Singh, Mallika, Hansen, Rich, Goldsmith, Mark A., Quintana, Elsa, Smith, Jacqueline A. M., Lowell, Clifford A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550718/
https://ncbi.nlm.nih.gov/pubmed/33133093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.576310
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