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Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model

PURPOSE: Efficacy of treosulfan, used in the treatment of marrow disorders, depends on the activity of its monoepoxy—(EBDM) and diepoxy compounds. The study aimed to describe the pharmacokinetics of treosulfan and EBDM in the rat plasma and brain by means of mixed-effects modelling. METHODS: The stu...

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Bibliografiske detaljer
Udgivet i:Pharmacol Rep
Main Authors: Danielak, Dorota, Romański, Michał, Kasprzyk, Anna, Teżyk, Artur, Główka, Franciszek
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550288/
https://ncbi.nlm.nih.gov/pubmed/32474888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43440-020-00115-0
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