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A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR
The mitochondrial unfolded protein response (UPR(mt)) is a stress-activated pathway promoting mitochondrial recovery and defense against infection. In C. elegans, the UPR(mt) is activated during infection with the pathogen Pseudomonas aeruginosa—but only transiently. As this may reflect a pathogenic...
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| Pubblicato in: | PLoS Pathog |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7549759/ https://ncbi.nlm.nih.gov/pubmed/32997715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008918 |
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