Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors

BACKGROUND: MEDI9197 is an intratumorally administered toll-like receptor 7 and 8 agonist. In mice, MEDI9197 modulated antitumor immune responses, inhibited tumor growth and increased survival. This first-time-in-human, phase 1 study evaluated MEDI9197 with or without the programmed cell death ligan...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Siu, Lillian, Brody, Joshua, Gupta, Shilpa, Marabelle, Aurélien, Jimeno, Antonio, Munster, Pamela, Grilley-Olson, Juneko, Rook, Alain H, Hollebecque, Antoine, Wong, Rebecca K S, Welsh, James W, Wu, Yuling, Morehouse, Christopher, Hamid, Oday, Walcott, Farzana, Cooper, Zachary A, Kumar, Rakesh, Ferté, Charles, Hong, David S
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Oncolytic and Local Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549442/
https://ncbi.nlm.nih.gov/pubmed/33037117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001095
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