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Intratumoral Anti-CTLA-4 Therapy: Enhancing Efficacy While Avoiding Toxicity
Systemic administration of the checkpoint blockade antibody anti-CTLA4 results in severe auto-immune toxicity, limiting its clinical efficacy. Fransen and colleagues show here that peri-tumoral delivery of low doses of this immunomodulatory drug can trigger a systemic anti-tumor immune response whil...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3817012/ https://ncbi.nlm.nih.gov/pubmed/23965900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1923 |
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