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Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs
[Image: see text] Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase, exerts kinase-dependent enzymatic functions and kinase-independent scaffolding functions, both of which are crucial in cancer development, early embryonic development, and reproduction. However, previous efforts fo...
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| Veröffentlicht in: | ACS Med Chem Lett |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2019
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7549110/ https://ncbi.nlm.nih.gov/pubmed/33062164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00372 |
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