Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders

[Image: see text] Human Macrophage Migration Inhibitory Factor (MIF) is a trimeric cytokine implicated in a number of inflammatory and autoimmune diseases and cancer. We previously reported that the dye p425 (Chicago Sky Blue), which bound MIF at the interface of two MIF trimers covering the tautome...

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Udgivet i:ACS Med Chem Lett
Main Authors: Cirillo, Pier F., Asojo, Oluwatoyin A., Khire, Uday, Lee, Yashang, Mootien, Sara, Hegan, Peter, Sutherland, Alan G., Peterson-Roth, Elizabeth, Ledizet, Michel, Koski, Raymond A., Anthony, Karen G.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549106/
https://ncbi.nlm.nih.gov/pubmed/33062162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00351
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