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Regulation of Lung Macrophage Activation and Oxidative Stress Following Ozone Exposure by Farnesoid X Receptor

Inflammatory macrophages are known to contribute to ozone toxicity. Farnesoid X receptor (FXR) is a nuclear receptor involved in regulating bile acid and lipid homeostasis; it also exerts anti-inflammatory activity by suppressing macrophage NF-κB. Herein, we analyzed the role of FXR in regulating ma...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Francis, Mary, Guo, Grace, Kong, Bo, Abramova, Elena V, Cervelli, Jessica A, Gow, Andrew J, Laskin, Jeffrey D, Laskin, Debra L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548292/
https://ncbi.nlm.nih.gov/pubmed/32984886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa111
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