Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alirocumab in Healthy Chinese Subjects: A Randomized, Double-Blind, Placebo-Controlled, Ascending Single-Dose Study

BACKGROUND: The addition of alirocumab (a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 [PCSK9]) to background statin therapy provides significant incremental low-density lipoprotein cholesterol (LDL-C) lowering and cardiovascular event risk reduction. OBJECTIVES:...

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Bibliografische gegevens
Gepubliceerd in:Am J Cardiovasc Drugs
Hoofdauteurs: Li, Haiyan, Wei, Yudong, Yang, Zhenhua, Zhang, Shuang, Xu, Xiuxiu, Shuai, Mengmeng, Vitse, Olivier, Wu, Yiwen, Baccara-Dinet, Marie T., Zhang, Yi, Li, Jianyong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2020
Onderwerpen:
Original Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548281/
https://ncbi.nlm.nih.gov/pubmed/32080823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40256-020-00394-1
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