Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase 2 Trial

PURPOSE: Pembrolizumab improved survival in recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC) patients. The aims of this study were to determine if pembrolizumab would be safe, result in pathologic tumor response (pTR), and lower the relapse rate in patients with resectable human...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Uppaluri, Ravindra, Campbell, Katie M., Egloff, Ann Marie, Zolkind, Paul, Skidmore, Zachary L., Nussenbaum, Brian, Paniello, Randal C., Rich, Jason T., Jackson, Ryan, Pipkorn, Patrik, Michel, Loren P., Ley, Jessica, Oppelt, Peter, Dunn, Gavin P., Barnell, Erica K., Spies, Nicholas C., Lin, Tianxiang, Li, Tiantian, Mulder, David T., Hanna, Youstina, Cirlan, Iulia, Pugh, Trevor J., Mudianto, Tenny, Riley, Rachel, Zhou, Liye, Jo, Vickie, Stachler, Matthew, Hanna, Glenn J., Kass, Jason, Haddad, Robert, Schoenfeld, Jonathan D., Gjini, Evisa, Lako, Ana, Thorstad, Wade, Gay, Hiram A., Daly, Mackenzie, Rodig, Scott J., Hagemann, Ian S., Kallogjeri, Dorina, Piccirillo, Jay F., Chernock, Rebecca D., Griffith, Malachi, Griffith, Obi L., Adkins, Douglas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547532/
https://ncbi.nlm.nih.gov/pubmed/32665297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1695
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