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Oral Cavity Squamous Cell Carcinoma Xenografts Retain Complex Genotypes and Intertumor Molecular Heterogeneity

Herein, we report an oral cavity squamous cell carcinoma (OCSCC) patient-derived xenograft (PDX) platform, with genomic annotation useful for co-clinical trial and mechanistic studies. Genomic analysis included whole-exome sequencing (WES) and transcriptome sequencing (RNA-seq) on 16 tumors and matc...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Campbell, Katie M., Lin, Tianxiang, Zolkind, Paul, Barnell, Erica K., Skidmore, Zachary L., Winkler, Ashley E., Law, Jonathan H., Mardis, Elaine R., Wartman, Lukas D., Adkins, Douglas R., Chernock, Rebecca D., Griffith, Malachi, Uppaluri, Ravindra, Griffith, Obi L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417872/
https://ncbi.nlm.nih.gov/pubmed/30134176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.058
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