Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

BACKGROUND: Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms controlling this special sterile inflammation after SCI are still not fully eluci...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Fan, Hong, Tang, Hai-Bin, Chen, Zhe, Wang, Hu-Qing, Zhang, Lei, Jiang, Yu, Li, Tao, Yang, Cai-Feng, Wang, Xiao-Ya, Li, Xia, Wu, Sheng-Xi, Zhang, Gui-Lian
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547440/
https://ncbi.nlm.nih.gov/pubmed/33036632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01973-4
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