HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia

BACKGROUND: Microglial mediated neuroinflammation in the rostral ventrolateral medulla (RVLM) plays roles in the etiology of stress-induced hypertension (SIH). It was reported that autophagy influenced inflammation via immunophenotypic switching of microglia. High-mobility group box 1 (HMGB1) acts a...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Zhang, Shutian, Hu, Li, Jiang, Jialun, Li, Hongji, Wu, Qin, Ooi, Kokwin, Wang, Jijiang, Feng, Yi, Zhu, Danian, Xia, Chunmei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953162/
https://ncbi.nlm.nih.gov/pubmed/31924219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1673-3
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