Microglia-Derived NLRP3 Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive Rats

Increased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla (RVLM) have been implicated in stress-induced hypertension (SIH). Prorenin, a member of the brain renin-angiotensin system (RAS), can directly activate microglia. The presen...

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Detalhes bibliográficos
Publicado no:Neurosci Bull
Main Authors: Hu, Li, Zhang, Shutian, Ooi, Kokwin, Wu, Xuehai, Wu, Jiaxiang, Cai, Jian, Sun, Yinggang, Wang, Jijiang, Zhu, Danian, Chen, Fuxue, Xia, Chunmei
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186257/
https://ncbi.nlm.nih.gov/pubmed/32242284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-020-00484-9
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