NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation

The transcription factor nuclear factor I-A (NFIA) is a regulator of brown adipocyte differentiation. Here we show that the C-terminal 17 amino acid residues of NFIA (which we call pro#3 domain) are required for the transcriptional activity of NFIA. Full-length NFIA—but not deletion mutant lacking p...

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Publicat a:PLoS Genet
Autors principals: Hiraike, Yuta, Waki, Hironori, Miyake, Kana, Wada, Takahito, Oguchi, Misato, Saito, Kaede, Tsutsumi, Shuichi, Aburatani, Hiroyuki, Yamauchi, Toshimasa, Kadowaki, Takashi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546476/
https://ncbi.nlm.nih.gov/pubmed/32991581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009044
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