Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition

BACKGROUND: Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease. Herein we report the synergistic antitumor interaction between two well-known drugs used for years in clinical pr...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Iannelli, Federica, Roca, Maria Serena, Lombardi, Rita, Ciardiello, Chiara, Grumetti, Laura, De Rienzo, Simona, Moccia, Tania, Vitagliano, Carlo, Sorice, Angela, Costantini, Susan, Milone, Maria Rita, Pucci, Biagio, Leone, Alessandra, Di Gennaro, Elena, Mancini, Rita, Ciliberto, Gennaro, Bruzzese, Francesca, Budillon, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545949/
https://ncbi.nlm.nih.gov/pubmed/33032653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01723-7
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