Downregulation of MEG3 promotes neuroblastoma development through FOXO1-mediated autophagy and mTOR-mediated epithelial-mesenchymal transition

Our previous studies demonstrated that MEG3 was significantly downregulated in neuroblastoma (NB) and its expression was negatively associated with the INSS stage. Overexpression of MEG3 promoted apoptosis and inhibited proliferation in NB cells. In this study, we discovered more potential functions...

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Publicat a:Int J Biol Sci
Autors principals: Ye, Mujie, Lu, Hong, Tang, Weitao, Jing, Tianrui, Chen, Shiyu, Wei, Meng, Zhang, Jingjing, Wang, Jing, Ma, Jing, Ma, Duan, Dong, Kuiran
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545718/
https://ncbi.nlm.nih.gov/pubmed/33061817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.48126
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