Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

BACKGROUND: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain that plays a central role in microglia activation in response...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Franzmeier, Nicolai, Suárez-Calvet, M., Frontzkowski, Lukas, Moore, Annah, Hohman, Timothy J., Morenas-Rodriguez, Estrella, Nuscher, Brigitte, Shaw, Leslie, Trojanowski, John Q., Dichgans, Martin, Kleinberger, Gernot, Haass, Christian, Ewers, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545547/
https://ncbi.nlm.nih.gov/pubmed/33032659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00407-2
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