Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism

Hyper-virulent Streptococcus pneumoniae serotype 1 strains are endemic in Sub-Saharan Africa and frequently cause lethal meningitis outbreaks. It remains unknown whether genetic variation in serotype 1 strains modulates tropism into cerebrospinal fluid to cause central nervous system (CNS) infection...

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Publicat a:Commun Biol
Autors principals: Chaguza, Chrispin, Yang, Marie, Cornick, Jennifer E., du Plessis, Mignon, Gladstone, Rebecca A., Kwambana-Adams, Brenda A., Lo, Stephanie W., Ebruke, Chinelo, Tonkin-Hill, Gerry, Peno, Chikondi, Senghore, Madikay, Obaro, Stephen K., Ousmane, Sani, Pluschke, Gerd, Collard, Jean-Marc, Sigaùque, Betuel, French, Neil, Klugman, Keith P., Heyderman, Robert S., McGee, Lesley, Antonio, Martin, Breiman, Robert F., von Gottberg, Anne, Everett, Dean B., Kadioglu, Aras, Bentley, Stephen D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545184/
https://ncbi.nlm.nih.gov/pubmed/33033372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01290-9
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