Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Brain cells continuously produce and release protons into the extracellular space, with the rate of acid production corresponding to the levels of neuronal activity and metabolism. Efficient buffering and removal of excess H(+) is essential for brain function, not least because all the electrogenic...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Theparambil, Shefeeq M., Hosford, Patrick S., Ruminot, Iván, Kopach, Olga, Reynolds, James R., Sandoval, Pamela Y., Rusakov, Dmitri A., Barros, L. Felipe, Gourine, Alexander V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545092/
https://ncbi.nlm.nih.gov/pubmed/33033238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18756-3
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