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Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Brain cells continuously produce and release protons into the extracellular space, with the rate of acid production corresponding to the levels of neuronal activity and metabolism. Efficient buffering and removal of excess H(+) is essential for brain function, not least because all the electrogenic...

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Publicado en:Nat Commun
Autores principales: Theparambil, Shefeeq M., Hosford, Patrick S., Ruminot, Iván, Kopach, Olga, Reynolds, James R., Sandoval, Pamela Y., Rusakov, Dmitri A., Barros, L. Felipe, Gourine, Alexander V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545092/
https://ncbi.nlm.nih.gov/pubmed/33033238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18756-3
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