Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located in skeletal muscles, indicating that muscles...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Pirkmajer, Sergej, Bezjak, Katja, Matkovič, Urška, Dolinar, Klemen, Jiang, Lake Q., Miš, Katarina, Gros, Katarina, Milovanova, Kseniya, Pirkmajer, Katja Perdan, Marš, Tomaž, Kapilevich, Leonid, Chibalin, Alexander V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544989/
https://ncbi.nlm.nih.gov/pubmed/33101052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.566584
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