Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located in skeletal muscles, indicating that muscles...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Pirkmajer, Sergej, Bezjak, Katja, Matkovič, Urška, Dolinar, Klemen, Jiang, Lake Q., Miš, Katarina, Gros, Katarina, Milovanova, Kseniya, Pirkmajer, Katja Perdan, Marš, Tomaž, Kapilevich, Leonid, Chibalin, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544989/
https://ncbi.nlm.nih.gov/pubmed/33101052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.566584
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