Reactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell Therapy

Adoptive T cell therapy (ACT) in combination with lymphodepleting chemotherapy is an effective strategy to induce the eradication of tumors, providing long-term regression in cancer patients. Despite that lymphodepleting regimens condition the host for optimal engraftment and expansion of adoptively...

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Pubblicato in:Mol Ther
Autori principali: Innamarato, Patrick, Kodumudi, Krithika, Asby, Sarah, Schachner, Benjamin, Hall, MacLean, Mackay, Amy, Wiener, Doris, Beatty, Matthew, Nagle, Luz, Creelan, Ben C., Sarnaik, Amod A., Pilon-Thomas, Shari
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544980/
https://ncbi.nlm.nih.gov/pubmed/32615068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.06.025
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