Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models

Chimeric antigen receptor T cell therapy (CAR-T) has been rolled out as a new treatment for hematological malignancies. For solid tumor treatment, CAR-T has been disappointing so far. Challenges include the quantification of CAR-T trafficking, expansion and retention in tumors, activity at target si...

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Bibliografiska uppgifter
I publikationen:Mol Ther
Huvudupphovsmän: Volpe, Alessia, Lang, Cameron, Lim, Lindsay, Man, Francis, Kurtys, Ewelina, Ashmore-Harris, Candice, Johnson, Preeth, Skourti, Elena, de Rosales, Rafael T.M., Fruhwirth, Gilbert O.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2020
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544977/
https://ncbi.nlm.nih.gov/pubmed/32645298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.06.028
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