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The clinical potential of gene editing as a tool to engineer cell-based therapeutics

The clinical application of ex vivo gene edited cell therapies first began a decade ago with zinc finger nuclease editing of autologous CD4(+) T-cells. Editing aimed to disrupt expression of the human immunodeficiency virus co-receptor gene CCR5, with the goal of yielding cells resistant to viral en...

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Bibliografische gegevens
Gepubliceerd in:Clin Transl Med
Hoofdauteurs: Ashmore-Harris, Candice, Fruhwirth, Gilbert O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007464/
https://ncbi.nlm.nih.gov/pubmed/32034584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40169-020-0268-z
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