Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: an in silico structure-based approach

In this study, the Nsp12–Nsp8 complex of SARS-CoV-2 was targeted with structure-based and computer-aided drug design approach because of its vital role in viral replication. Sequence analysis of RNA-dependent RNA polymerase (Nsp12) sequences from 30,366 different isolates were analysed for possible...

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Detalhes bibliográficos
Publicado no:J Biomol Struct Dyn
Main Authors: Mutlu, Ozal, Ugurel, Osman Mutluhan, Sariyer, Emrah, Ata, Oguz, Inci, Tugba Gul, Ugurel, Erennur, Kocer, Sinem, Turgut-Balik, Dilek
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544933/
https://ncbi.nlm.nih.gov/pubmed/32933378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2020.1819882
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