Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis

The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney disease, upregulated CD248 in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Pai, Chen-Hsueh, Lin, Shu-Rung, Liu, Chia-Hao, Pan, Szu-Yu, Hsu, Hao, Chen, Yi-Ting, Yen, Ching-Tzu, Yu, I-Shing, Wu, Hua-Lin, Lin, Shuei-Liong, Lin, Shu-Wha
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544830/
https://ncbi.nlm.nih.gov/pubmed/33033277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73194-x
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