Surgery, Anesthesia and Intensive Care Environment Induce Delirium-Like Behaviors and Impairment of Synaptic Function-Related Gene Expression in Aged Mice

OBJECTIVE: To establish a clinically relevant mouse model of perioperative delirium. METHODS: Aged C57BL/6J mice were tested at baseline in the Y-maze novel arm preference, buried food, simple discrimination task of the attentional set-shifting test, and open field tests. They were subsequently rand...

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Detalles Bibliográficos
Publicado en:Front Aging Neurosci
Main Authors: Illendula, Meghana, Osuru, Hari Prasad, Ferrarese, Bianca, Atluri, Navya, Dulko, Elzbieta, Zuo, Zhiyi, Lunardi, Nadia
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544741/
https://ncbi.nlm.nih.gov/pubmed/33088271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.542421
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