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HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri

Primary amebic meningoencephalitis (PAM), caused by the free-living ameba Naegleria fowleri, has a fatality rate of over 97%. Treatment of PAM relies on amphotericin B in combination with other drugs, but few patients have survived with the existing drug treatment regimens. Therefore, development of...

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Опубликовано в: :ACS Chem Neurosci
Главные авторы: Hahn, Hye Jee, Abagyan, Ruben, Podust, Larissa M., Roy, Shantanu, Ali, Ibne Karim M., Debnath, Anjan
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544672/
https://ncbi.nlm.nih.gov/pubmed/32881478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00428
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