On-Tissue Derivatization with Girard’s Reagent P Enhances N-Glycan Signals for Formalin-Fixed Paraffin-Embedded Tissue Sections in MALDI Mass Spectrometry Imaging

[Image: see text] Glycosylation is a major protein post-translational modification whose dysregulation has been associated with many diseases. Herein, an on-tissue chemical derivatization strategy based on positively charged hydrazine reagent (Girard’s reagent P) coupled with matrix-assisted laser d...

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Pubblicato in:Anal Chem
Autori principali: Zhang, Hua, Shi, Xudong, Vu, Nhu Q., Li, Gongyu, Li, Zihui, Shi, Yatao, Li, Miyang, Wang, Bin, Welham, Nathan V., Patankar, Manish S., Weisman, Paul, Li, Lingjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544651/
https://ncbi.nlm.nih.gov/pubmed/32865977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c02704
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