A Membrane-Bound Diacylglycerol Species Induces PKCɛ-Mediated Hepatic Insulin Resistance

Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance (HIR); however, the key lipid species and molecular mechanisms linking these conditions are widely debated. We developed a subcellular fractionation method to quantify diacylglycerol (DAG) stereoisomers and ceram...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Lyu, Kun, Zhang, Ye, Zhang, Dongyan, Kahn, Mario, ter Horst, Kasper W., Rodrigues, Marcos R. S., Gaspar, Rafael C., Hirabara, Sandro M., Luukkonen, Panu K., Lee, Seohyuk, Bhanot, Sanjay, Rinehart, Jesse, Blume, Niels, Rasch, Morten Grønbech, Serlie, Mireille J., Bogan, Jonathan S., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544641/
https://ncbi.nlm.nih.gov/pubmed/32882164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.08.001
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