Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates

Chimeric antigen receptor (CAR) T cells targeting CD19(+) hematologic malignancies have rapidly emerged as a promising, novel therapy. In contrast, results from the few CAR T-cell studies for infectious diseases such as HIV-1 have been less convincing. These challenges are likely due to the low leve...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Rust, Blake J., Kean, Leslie S., Colonna, Lucrezia, Brandenstein, Katherine E., Poole, Nikhita H., Obenza, Willimark, Enstrom, Mark R., Maldini, Colby R., Ellis, Gavin I., Fennessey, Christine M., Huang, Meei-Li, Keele, Brandon F., Jerome, Keith R., Riley, James L., Kiem, Hans-Peter, Peterson, Christopher W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544543/
https://ncbi.nlm.nih.gov/pubmed/32614969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006372
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