Elements at the 5′ end of Xist harbor SPEN-independent transcriptional antiterminator activity

The Xist lncRNA requires Repeat A, a conserved RNA element located in its 5′ end, to induce gene silencing during X-chromosome inactivation. Intriguingly, Repeat A is also required for production of Xist. While silencing by Repeat A requires the protein SPEN, how Repeat A promotes Xist production re...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Trotman, Jackson B, Lee, David M, Cherney, Rachel E, Kim, Susan O, Inoue, Kaoru, Schertzer, Megan D, Bischoff, Steven R, Cowley, Dale O, Calabrese, J Mauro
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544216/
https://ncbi.nlm.nih.gov/pubmed/32986830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa789
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