A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin

Xist requires Repeat-A, a protein-binding module in its first two kilobases (2kb), to repress transcription. We report that when expressed as a standalone transcript in mouse embryonic stem cells (ESCs), the first 2kb of Xist (Xist-2kb) does not induce transcriptional silencing. Instead, Xist-2kb se...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lee, David M, Trotman, Jackson B, Cherney, Rachel E, Inoue, Kaoru, Schertzer, Megan D, Bischoff, Steven R, Cowley, Dale O, Calabrese, J Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
RNA and RNA-Protein Complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648342/
https://ncbi.nlm.nih.gov/pubmed/31114903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz432
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