Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde

Information is scarce regarding pharmacokinetic-based herb-drug interactions (HDI) with trans-cinnamaldehyde (CA) and 2-methoxycinnamaldehyde (MCA), components of cinnamon. Given the presence of cinnamon in food and herbal treatments for various diseases, HDIs involving the CYP2A6 substrates nicotin...

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Udgivet i:Drug Metab Dispos
Main Authors: Espiritu, Michael J., Chen, Justin, Yadav, Jaydeep, Larkin, Michael, Pelletier, Robert D., Chan, Jeannine M., GC, Jeevan B., Natesan, Senthil, Harrelson, John P.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2020
Fag:
Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543486/
https://ncbi.nlm.nih.gov/pubmed/32788161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000087
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