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Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole

Human exposure to trans-cinnamic aldehyde [t-CA; cinnamaldehyde; cinnamal; (E)-3-phenylprop-2-enal] is common through diet and through the use of cinnamon powder for diabetes and to provide flavor and scent in commercial products. We evaluated the likelihood of t-CA to influence metabolism by inhibi...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Chan, Jeannine, Oshiro, Tyler, Thomas, Sarah, Higa, Allyson, Black, Stephen, Todorovic, Aleksandar, Elbarbry, Fawzy, Harrelson, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810772/
https://ncbi.nlm.nih.gov/pubmed/26851241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.067942
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