Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis

Among the three nonmuscle myosin 2 (NM2) paralogs, NM 2A and 2B, but not 2C, are detected in endothelial cells. To study the role of NM2 in vascular formation, we ablate NM2 in endothelial cells in mice. Ablating NM2A, but not NM2B, results in reduced blood vessel coverage and increased vascular bra...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Ma, Xuefei, Uchida, Yutaka, Wei, Tingyi, Liu, Chengyu, Adams, Ralf H., Kubota, Yoshiaki, Gutkind, J. Silvio, Mukouyama, Yoh-suke, Adelstein, Robert S.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543065/
https://ncbi.nlm.nih.gov/pubmed/32583739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-03-0175
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